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Opinions on madating hpv vaccine

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Unlike more common surgical treatments for cervical lesions, active immunotherapy has the potential to address HPV persistence as the cause of lesion development in addition to leaving the patient with long-term immunity that can be reactivated if and when the patient becomes reinfected.

Parts of the studies mentioned in this article were supported through grants from the National Institutes of Health (NIH) [NIH R01 CA74397 and NIH P01 CA97296], the V Foundation, and the Whittier Foundation (to Dr Kast). The authors claim no financial conflicts of interest that are directly relevant to the contents and opinions expressed in this article.

Dr Da Silva is supported in part by a postdoctoral research training fellowship NCI T32 CA009320.

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Two major phase II clinical trials conducted by pharmaceutical companies have demonstrated that their vaccines have 100% efficacy in preventing persistent viral DNA and its associated cellular abnormalities; however, whether they induce long-lasting protective immunity is yet to be determined.

At least one US FDA approved prophylactic vaccine targeting the two most common high-risk HPVs is expected to be on the market within the next 2–3 years.

Nevertheless, significant reductions in the frequency and onset of cytologic screening and incidences of HPV-related lesions are not expected to become apparent for decades due to the fact that there will be women who are already infected with HPV, the long latency period between infection and development of high-grade lesions, and lesions associated with other high-risk HPV types not being included in the vaccines.

Therapeutic vaccines aim to control HPV-associated malignancies by stimulating cellular immune responses that target established HPV infections via viral proteins.

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